Dravet Syndrome Seizure Treatment Options People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome. Fintepla Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome. Medications for Dravet Syndrome Seizures Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity. Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects. Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals. [youmaylike] Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects. Dietary Approaches: The Ketogenic Diet For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures. The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet. Vagus Nerve Stimulation (VNS) Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe. VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments. Surgical Options In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved. Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery. Supportive Therapies While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include: Physical therapy: This helps improve mobility and strength, which can be affected by seizures. Occupational therapy: Helps individuals learn daily skills to live as independently as possible. Speech therapy: Helps improve communication skills, which may be affected by seizures. Ongoing Monitoring and Care Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options. The Best Approaches to Seizure Control While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.
CP and CPPS: What is It?
Chronic prostatitis or chronic pelvic pain syndrome is a condition that affects the urinary or genital organs. The disease is an inflammation of the prostate and irritation of the nerves around it characterized by chronic pain and discomfort intervals.
The disease is poorly understood and presently has no cure. It causes erectile dysfunction, urinary and bowel problems that undermine a man’s quality of life and often lead to depression.
Symptoms and Causes of Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Chronic prostatitis or chronic pelvic pain syndrome is the most common form of prostatitis. Some symptoms include:
- Pelvic pain
- Sexual dysfunction, including painful ejaculations
- Difficulty or pain passing urine, voiding challenges, or burning sensation while urinating
- Irregular intervals of pain in the bladder, testicles, and penis and up to the anus
For a person to get a CPPS diagnosis, the pelvic pain must have persisted for at least six months. While the exact cause of CPPS is unknown, doctors think either a recurring infection or inflammation of the prostate due to physical trauma may be the cause of it. The initial infection or physical trauma to the pelvic goes undetected, causing nerve damage to the genitourinary (urinary and genital organs) area. With time, the damage spreads to the bladder, ligaments, and pelvic floor muscles. If treatment is not given immediately, it results in pain sensitivity in the pelvic area.
Some risk factors of CPPS include occasions for bacteria entering your body, such as:
- A catheter or an equivalent device that’s placed in the urethra to help drain urine.
- Urinary tract disorders such as urinary tract infections (UTI) or interstitial cystitis, among others.
Diagnosis
A CPPS diagnosis entails using a scoring matrix to eliminate other diseases and checking against any prevalent comorbidities. The tool used to score the symptom is called the International Prostate Symptom Score.
Another tool called the UNPOINT is increasingly becoming popular in the diagnosis of CPPS. The tool classifies the symptoms according to:
- Urinary
- Psychosocial
- Organ-specific
- Infection
- Neurological/systemic
- Tenderness
After the scoring, the doctor or examiner will then undertake physical examinations to assess the abdomen and external genitalia. The examiner may also perform a digital rectal examination. The digital exam will show if the prostate is tender on palpation. It also enables the doctor to examine the pelvic floor muscles and their ability to contract or relax.
Lastly, the medical examiner may want to rule out other pain-causing pathogens. The examiner may carry out additional tests such as:
- Urine dipstick test or an early morning urine specimen
- Urethral swab and culture if urethritis becomes a concern
- Uroflowmetry to calculate the flow rate of your urine
- Retrograde urethrography and a bladder scan to determine the ease at which urine flows from the bladder
- Cystoscopy to examine the lining of the bladder and exclude other causes such as a stricture
- Magnetic resonance imaging (MRI) and computerized tomography (CT) to help rule out the possibility of pus in the prostate
- A blood test to measure prostate-specific antigen PSA levels to rule out prostate cancer
Afterward, the examiner will check for evidence of sexual abuse and will test for depression and generalized anxiety disorder (GAD) as comorbidity. He or she may also subject you to a self-assessment questionnaire to better understand your pain levels and mental health.
Treatment Options for CPPS
CPPS is treated using antibiotics, anti-inflammation medication, or alpha-blockers.
Antibiotics
Antibiotics are used to treat bacterial infections that may be the underlying cause of CPPS. However, there is some controversy around using antibiotics because doctors prescribe them even when patients do not test positive for bacterial infection.
The doctors who prescribe antibiotics without a negative test believe bacteria may be present in the prostrate's glands or stroma without entering the urinary tract.
However, antibiotics can only be used for a limited time, usually four weeks, especially for newly diagnosed patients. The antibiotics used in this case are those with non-inflammation properties.
Anti-inflammation Medication
Aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen reduce the pain men experience when dealing with chronic prostatitis or chronic pelvic pain syndrome. However, NSAIDs are not effective by themselves and are used together with alpha-blockers.
Alpha-Blockers
Doctors use alpha-blockers to treat Benign Prostatic Hyperplasia (BPH) prescribed for CPPS because it relaxes the urinary tract muscles, allowing the free passing of urine. However, research shows that men newly diagnosed with CPPS are more likely to respond positively to alpha-blockers. The effectiveness of alpha-blockers diminishes after a six-month treatment course.