Dravet Syndrome Seizure Treatment Options People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome. Fintepla Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome. Medications for Dravet Syndrome Seizures Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity. Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects. Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals. [youmaylike] Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects. Dietary Approaches: The Ketogenic Diet For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures. The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet. Vagus Nerve Stimulation (VNS) Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe. VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments. Surgical Options In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved. Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery. Supportive Therapies While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include: Physical therapy: This helps improve mobility and strength, which can be affected by seizures. Occupational therapy: Helps individuals learn daily skills to live as independently as possible. Speech therapy: Helps improve communication skills, which may be affected by seizures. Ongoing Monitoring and Care Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options. The Best Approaches to Seizure Control While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.
What is Crohn's Disease?
Crohn's disease is an inflammatory bowel disease (IBD) characterized by mild or chronic inflammation of parts of the digestive tract. It is estimated that 780,000 U.S. citizens have Crohn’s disease. These statistics cause concern because researchers have yet to identify the causes of the disease, or a cure.
Although Crohn's disease is not life-threatening, it can cause fatal complications.
Causes and Symptoms of Crohn's Disease
There are common ecological, heredity, and immune system factors found amid patients with IBD.
People living in developed nations, urban, and northern climates are more likely to have IBD compared with the people in underdeveloped, rural, and Southern climates.
Research shows that Crohn's disease is common in families with a history of IBD. Up to 20% of patients with IBD have a parent, child, or sibling with Crohn's or an IBD type of disease.
A healthy person's immune system pushes white blood into the gastrointestinal tract to launch an attack on bacteria and other harmful microorganisms. During the attack, the immune system spares the beneficial bacteria in the digestive tract. Inflammation occur in periods when the immune system is on the defense.
However, with IBD patients, the immune system does not differentiate between harmful and beneficial bacteria. Further, the inflammation that occurs during the immune response does not subside. It becomes chronic and causes ulcers and the intestinal walls thicken.
The most common symptoms of Crohn's disease include:
- Fever
- Fatigue
- Blood in the stool
- Unexplained weight loss
- Abdominal cramps
- Loss of appetite
- Abdominal pain
- Frequent diarrhea
Smoking, poor nutrition, and stress increase the severity of Crohn’s symptoms.
Strictures
Because of frequent inflammation, scar tissues that form in the intestinal wall cause the intestines to become narrow and consequently form strictures. Repeated inflammation and scarring of the small intestines may cause the scars to rupture.
Ulcers
The main characteristic of Crohn's disease is an inflamed intestinal lining. The inflammation causes changes to the intestinal lining, the mucosa, and the thickness of the intestinal walls, which leads to ulcers. Inflamed stomach, mouth or intestinal walls make eating and feeding very hard for the patient.
Fistulas and Anal Fissures
Fistulas and fissures are among the severe symptoms of Crohn's disease. Fistulas are connections or holes between an organ and the intestines. At the same time, fissures are painful tears in the anal tissues, which can expose the patient to other infections or lead to fistulas.
How is Crohn's Disease Diagnosed?
Doctors diagnose Crohn's through a process of elimination. A doctor will use several tests to diagnose and rule out likely causes of your symptoms. These tests range from stool tests to look for blood in your gut, colonoscopy, imaging tests like MRIs and CT scans, biopsy, or endoscopy.
By looking at the gut inside out, the doctor can then rule out other causes of symptoms and confirm Crohn's disease.
How is Crohn's Disease Treated?
There is no cure for Crohn's disease, but doctors can manage the disease through various ways such as administering antibiotics, steroids, immunosuppressant drugs, and anti-inflammatory drugs.
Doctors may also take other surgical measures depending on the severity symptoms, the extent of flare-ups, and the damage left in the intestines.
These measures include:
- Abscess drainage
- Colostomy or ileostomy
- Bowel resection (removal of some bowel sections with fistulas)
- Reconstructive surgery
To reduce flares and mitigate the severity of Crohn's doctors advise a change in diet. It's essential that you make an appointment with a registered dietitian capable of advising on the best foods to eat and foods to avoid.
It is also vital to keep a food diary and take note of your trigger foods or any information likely to be useful during follow up doctor appointments.
You should also be sure to take note of any prescription or over the counter medications you ingest. A diary helps the doctor trace the cause of a flare. For instance, aspirin in medications causes fire in the gut for people with gastro-intestinal issues.
As a start, increase your water intake and limit excessive fats and dairy in your diet. Look at the spices you use to cook. Chances are if your intestines are inflamed, some spices will make the pain more intense.
Talk to your doctor or dietitian regarding which supplements are best for you. Having an inflamed gut means absorbing fewer nutrients, hence the weight loss. It's essential to have alternative sources of nutrients to ensure to keep up with the body's needs.