Dravet Syndrome Seizure Treatment Options People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome. Fintepla Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome. Medications for Dravet Syndrome Seizures Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity. Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects. Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals. [youmaylike] Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects. Dietary Approaches: The Ketogenic Diet For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures. The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet. Vagus Nerve Stimulation (VNS) Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe. VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments. Surgical Options In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved. Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery. Supportive Therapies While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include: Physical therapy: This helps improve mobility and strength, which can be affected by seizures. Occupational therapy: Helps individuals learn daily skills to live as independently as possible. Speech therapy: Helps improve communication skills, which may be affected by seizures. Ongoing Monitoring and Care Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options. The Best Approaches to Seizure Control While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.
Cyclothymic Disorder: A Mood Disorder
The cyclothymic disorder, also known as cyclothymia, is a mood disorder milder than bipolar I or II. It is characterized by a successive series of hypomania and depressive lows. The highs and lows are mild, with the depressive lows never reaching major depression and the hypomania never culminating in actual mania.
However, since all mental illnesses are on a continuum, cyclothymia may also range from normal mood variations to severe functional impairment because of the disorder. Individuals with cyclothymia are at risk of developing bipolar or other severe mood disorders if they cannot manage the condition properly with the help of a doctor.
The high and low periods are irregular and unpredictable. The low periods may last several days or weeks, but the person may experience normal moods for more than a month between the high and low.
Symptoms of Cyclothymic Disorder
Diagnostic and Statistical Manual of Mental Disorders (DSM-5) categorizes cyclothymia’s symptoms into depressive and manic symptoms.
Depressive related symptoms may include:
- Aggressiveness
- Changes in appetite
- Chronic fatigue or low energy
- Feelings of worthlessness and guilt
- Inattentiveness and forgetfulness
- Irritability
- Insomnia or hypersomnia without fatigue
- Weight changes
- Low libido
- Tearfulness, sadness, or feeling empty
- Loss of interests in things that were once enjoyed
- Poor concentration
- Suicidal thoughts
The manic symptoms of cyclothymia may include:
- Extremely combative
- Extreme optimism
- When talking, they speak fast and excessively
- Having little or no sleep for days (without feeling tired)
- Hypersexuality
- Increased anxiety
- Inflated self-esteem
- Irregular sleep cycle
- Lack of focus
- Racing thoughts
- Poor judgment and risky behavior
- High drive and a strong desire to achieve goals
- Restlessness and hyperactivity
Causes of Cyclothymic Disorder
The underlying causes of the cyclothymic disorder are unknown. However, there is a heredity aspect of it since it may run in families. Cyclothymia may also result from negative neurological changes of the brain caused by:
- Alcohol use disorder
- Stroke
- PTSD
- Alzheimer disease
- Migraines
- Brain aneurysm
- Concussion
- Multiple sclerosis
Cyclothymic Diagnosis
In the diagnosis of a cyclothymic disorder, your doctor may:
- Perform a physical exam which may include a lab test to find an explanation of your symptoms.
- Undertake a psychological evaluation, which entails talking about your thoughts and how they affect your feelings and behavior. The doctor may engage your family members and close friends to discuss your behavior but only with your express consent. Your doctor may also ask you to fill out a self-assessment questionnaire.
- Your doctor may require that you keep a journal recording your mood and sleep patterns.
According to the DSM-5, you may have cyclothymia if your doctor discovers that you have:
- Periods of elevated mood and depressive episodes lasting two years for adults and one for children and teens.
- You’ve not had a stable mood for periods not exceeding two months.
- Your symptoms significantly affect your social life, work, or school.
- There is no other explanation for your symptoms (such as substance abuse).
- Your symptoms do not meet the criteria for bipolar, depression, or other mental disorders.
Cyclothymic Disorder Treatment Options
People with cyclothymia need full-time medication to manage their condition, primarily because of the risk that the disease may progress into bipolar disorder if not treated. Whereas there is no medication specifically to treat cyclothymia, your doctor may rely on treatments used to treat other conductions such as:
- Anti-anxiety medication
- Antidepressants such as Prozac, Paxil, or Zoloft
- Anti-epileptic medication
- Anti-seizure meds
- Avoid alcohol and substance use or abuse
- Mood stabilizers such as lithium or lamotrigine
- Atypical antipsychotic medication
These medications can help manage the symptoms of the disorder and prevent the hypomanic and depressive cycles.
Cognitive-behavioral therapy (CBT) is another treatment option. Your doctor may recommend CBT combined with medication. It focuses on identifying negative thought patterns that lead to behavioral problems. CBT also imparts mechanisms to cope with stress. CBT is an effective form of psychotherapy that allows the patient to identify, avoid, or cope with triggers.
The other psychotherapeutic option is interpersonal and social rhythm therapy (IPSRT). IPSRT supports the patient to achieve a daily rhythm of activities such as sleeping, waking up, and mealtimes. A predetermined and consistent routine is one way of guaranteeing a better mood. Your therapies may also recommend physical exercises and diet or connect you to a professional.
