Dravet Syndrome Seizure Treatment Options People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome. Fintepla Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome. Medications for Dravet Syndrome Seizures Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity. Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects. Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals. [youmaylike] Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects. Dietary Approaches: The Ketogenic Diet For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures. The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet. Vagus Nerve Stimulation (VNS) Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe. VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments. Surgical Options In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved. Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery. Supportive Therapies While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include: Physical therapy: This helps improve mobility and strength, which can be affected by seizures. Occupational therapy: Helps individuals learn daily skills to live as independently as possible. Speech therapy: Helps improve communication skills, which may be affected by seizures. Ongoing Monitoring and Care Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options. The Best Approaches to Seizure Control While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.
Fatty Liver Disease Symptoms to Know About
The liver is the largest organ in the body, helping in food digestion, energy storage, and detoxification. The liver typically contains some fat; however, excessive build-up of this fat causes fatty liver disease. In this article we discuss fatty liver disease symptoms and how you can manage it.
But first, there are two main types of fatty liver disease:
Non-alcoholic Fatty Liver Disease (NAFLD)
As the name implies, this type of fatty liver disease is not associated with heavy alcohol use. There are two kinds:
- Simple fatty liver: This is a less serious case that involves little or no inflammation or liver cell damage together with the fat build-up.
- Non-alcoholic steatohepatitis (NASH): In this case, fat builds up in the liver, together with inflammation or liver cell damage. Inflammation and liver cell damage can cause fibrosis, or scarring, of the liver. This may also lead to cirrhosis or liver cancer.
Alcoholic Fatty Liver Disease
Also called alcoholic steatohepatitis, this is usually a result of heavy alcohol use. The liver is responsible for breaking down most of the alcohol you drink so that your body can remove it. However, while breaking down alcohol, certain harmful substances that can damage liver cells, promote inflammation, and weaken your body's natural defenses are generated. The more alcohol you drink, the more you damage your liver.
What Causes Fatty Liver Disease?
As earlier stated, fatty liver develops when your body produces too much fat or does not metabolize fat efficiently enough. The excess fat is stored in liver cells, where it accumulates and causes the disease. This build-up of fat is mostly caused by excessive alcohol consumption. This is the first stage of alcohol-related liver disease. In the case of people who do not drink a lot of alcohol, the cause of fatty liver disease is usually not certain.
Common Symptoms of Fatty Liver Disease
Both types of fatty liver disease are usually silent diseases with few or no symptoms. However, some symptoms such as tiredness or discomfort in the upper right side of your abdomen may occur. Some people with fatty liver disease also develop complications such as liver scarring. Liver scarring is known as liver fibrosis. In severe cases, it is known as cirrhosis.
How is Fatty Liver Disease Diagnosed?
Because there are often no symptoms, it can be challenging to diagnose fatty liver disease. However, your doctor may suspect that you have it if you get abnormal results on liver tests that you had for other reasons. For diagnosis, your doctor may rely on your medical history, physical examination, and various tests — including blood and imaging tests and sometimes a biopsy.
Medical History
Your doctor will ask about your alcohol use to determine whether fat in your liver is a sign of alcoholic fatty liver disease or non-alcoholic fatty liver (NAFLD). Your doctor may also want to find out about any drugs you have recently used to check if they contribute to the condition.
Physical Examination
During the physical examination, your doctor will examine your body and check your weight and height. Your doctor will look for any signs that may indicate fatty liver disease, such as an enlarged liver or signs of cirrhosis, e.g., jaundice.
Blood Tests
Your doctor might also recommend that you have blood tests, including liver function and blood count tests. In some cases, you may also have imaging tests that help check for fat and the stiffness of your liver (which could mean fibrosis).
Biopsy
In some cases, you may also need a liver biopsy to confirm the diagnosis and to check how badly your liver is damaged.
What Are the Treatment Options for Fatty Liver Disease?
There are no approved medicines to treat NAFLD, but studies are still being carried out to find a cure. The most important part of treating alcohol-related fatty liver disease is to stop drinking alcohol. If you need help dealing with alcohol addiction, you might need to see a therapist or enroll in an alcohol recovery program.
There are, however, medicines that can help, either by reducing your cravings or making you feel sick if you drink alcohol. With non-alcoholic fatty liver disease, doctors usually recommend weight loss to reduce fat in the liver, inflammation, and fibrosis. If your doctor suspects that a certain medicine is responsible for the condition, you will be advised to discontinue usage of the medication and to switch to another one.
When fatty liver disease worsens and leads to cirrhosis, the condition may be treated using medicines, operations, and other medical procedures. If the cirrhosis leads to liver failure, a liver transplant will be considered.
Lifestyle Changes to Help Manage Fatty Liver Disease
Making lifestyle changes is essential in treating fatty liver disease because they are the first-line treatment for fatty liver disease. Depending on your current condition and lifestyle habits, the following will go a long way to help:
- Maintaining a healthy weight
- Reducing your alcohol intake
- Eating a nutrient-rich diet that is low in excess calories, saturated fat, and trans fats
- Getting at least 30 minutes of exercise most days of the week