Dravet Syndrome Seizure Treatment Options People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome. Fintepla Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome. Medications for Dravet Syndrome Seizures Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity. Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects. Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals. [youmaylike] Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects. Dietary Approaches: The Ketogenic Diet For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures. The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet. Vagus Nerve Stimulation (VNS) Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe. VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments. Surgical Options In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved. Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery. Supportive Therapies While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include: Physical therapy: This helps improve mobility and strength, which can be affected by seizures. Occupational therapy: Helps individuals learn daily skills to live as independently as possible. Speech therapy: Helps improve communication skills, which may be affected by seizures. Ongoing Monitoring and Care Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options. The Best Approaches to Seizure Control While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.
Latex Allergy Symptoms to Be Aware Of
A latex allergy refers to your immune system’s reaction to some substances found in natural rubber. These proteins are retained during the production of latex products which can then trigger allergies. There are several ways in which you could get exposed to products made from latex, and these are:
- Skin contact from latex gloves
- By inhaling the powder — most sterile gloves are coated with corn starch powder which is displaced into the air on opening the gloves
- Some medical instruments contain rubber, and when they come in contact with blood, they can trigger an allergic reaction
- By contact with the mucous membranes lining the eyes, mouth, vagina, and rectum
Although a latex allergy is more common among health workers because of their frequent use of latex products, others at risk of developing the allergy include:
- Individuals who use condoms, urinary catheters, or work with rubber frequently
- People who are allergic to food, such as bananas, pineapples, tomatoes, potatoes, and apples
- People with bone marrow defects
- Those with several other allergies and asthma
Allergic reactions to latex do not manifest the same way for everyone and, based on this, they can be classified into two groups:
Contact Dermatitis
This can either be irritant or allergic. Irritant contact dermatitis occurs as a result of prolonged and continuous exposure to the constituents of latex materials. This type is mild and typically starts at about 12 hours after contact. It is characterized by itching, tingling sensations, and scaling of the affected area.
Allergic contact dermatitis, however, is severe and delayed. The reaction is from substances used in processing latex and can be about 24 hours after contact. It affects more areas of the body and takes a longer time to subside.
Hypersensitivity to Latex
This type of allergy is the most severe form. Although it is not common, when it occurs, it can be life-threatening. It can present as allergic rhinitis with malaise, fever, cramps, and itching. There could also be systemic conditions such as chest tightening, low blood pressure, difficulty breathing, and an increased heart rate. This type of allergic response requires an urgent visit to the emergency room.
Symptoms of a Latex Allergy
Latex allergy symptoms can vary and depend on how much of the allergen you came in contact with and how your body responds to them. They could be mild, moderate, or life-threatening. Some of the symptoms include itching, small bumps all over the skin with some redness, and pain.
Systemic allergic reactions can appear as:
- Rashes and swelling in parts of your body that didn’t make contact with latex products
- Redness of the face
- Nasal congestion
- Teary eyes
In some uncommon instances, anaphylaxis, which is a life-threatening allergic reaction, could occur. This manifests as:
- Oral, nasal, or facial swelling and pain
- Difficulty swallowing
- Difficulty breathing
How to Get Diagnosed
Most cases that present in the clinic are diagnosed based on their symptoms and history of contact with allergens, including latex. In people who do not have symptoms but are concerned that they may have latex allergies, a skin test can be done. Your skin test could be a:
- Scratch test — the latex allergen is applied on your skin’s outer surface and is scratched to get it absorbed
- Intradermal test — a tiny portion of allergen is injected just beneath your skin
- Patch test — this requires sticking a patch containing the allergen on your arm for about two days
The scratch and intradermal test results take about 15 minutes, but the patch test takes days. Also, an allergen specialist has to be present during any skin test to manage any severe reactions before they become life-threatening.
When visiting a clinic, it is vital that you inform the staff of your allergies so they can use alternative materials to avoid a reaction.
Examples of Products Containing Latex and Alternatives
When you think of latex products, it is easy to assume that most of them would be found within a hospital environment. Surprisingly, many common household materials contain latex, and as with most allergies, the more you are exposed to it, the worse the reaction becomes. Some of these household products include:
- Rubber dining and cooking utensils
- Children’s toys
- Rubber slippers and shoes
- Toothbrush handles
- Condoms and sanitary items
- Waterproof beds
- Rubber key handles, bands, stamps, and cords
- Rubber keys on controllers and calculators
Also, latex is included in some items such as balloons, checkout belts, buttons on machines, and gloves worn at restaurants during food preparation.
Therefore, it is important to be conscious of any latex materials in your household and have plastic or metallic alternatives for use. While shopping or using the atm, wear nylon gloves to reduce the chance of unconsciously coming in contact with latex materials.