Dravet Syndrome Seizure Treatment Options People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome. Fintepla Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome. Medications for Dravet Syndrome Seizures Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity. Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects. Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals. [youmaylike] Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects. Dietary Approaches: The Ketogenic Diet For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures. The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet. Vagus Nerve Stimulation (VNS) Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe. VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments. Surgical Options In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved. Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery. Supportive Therapies While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include: Physical therapy: This helps improve mobility and strength, which can be affected by seizures. Occupational therapy: Helps individuals learn daily skills to live as independently as possible. Speech therapy: Helps improve communication skills, which may be affected by seizures. Ongoing Monitoring and Care Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options. The Best Approaches to Seizure Control While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.
What is Macular Degeneration?
Macular degeneration is an eye disease, also known as age-related macular degeneration (AMD or ARMD). This condition can lead to loss of vision, especially for those over 60 years old. The disease is characterized by the thinning of the macular, a subsection of the retina, situated at the back layer of the eye and transmits what the eyes see in the brain through the optic nerve.
There are two types of AMD: wet macular degeneration and dry macular degeneration. Dry macular degeneration is characterized by yellow deposits, also known as drusen, in the macula. The drusen become bigger, increase in number as the disease advances, and then they begin to distort and blur your vision. The light sensitive cells in your macular thin out and die. As the disease progresses, you may develop a blind spot at the center of your vision until you lose central vision.
Wet macular degeneration is characterized by the growth of blood vessels form under the macula. The blood vessels leak blood and other fluids into your retina. This distorts your vision and causes straight lines to look bent. Eventually, the bleeding blood vessels scar, and cause a permanent loss of central vision.
90% of the people with AMD have the dry form even though, in some cases, it develops into the wet form.
Common Symptoms
Macular degeneration usually occurs progressively. Most patients with AMD have no pain, which means the disease is often caught at an advanced stage, having affected both eyes.
Common symptoms can include the following:
- Blurry and dark sections at the center of your vision
- Difficulty recognizing faces
- Distorted visions are causing wrong color perception and objects to appear bent or deformed
- An increasing need for light when reading and increased blurriness of printed text
- Difficulty visually adjusting when you move from a well-lit area to one that’s dimly lit
There are three stages of macular degeneration as follows:
- Early AMD: There is no vision loss. This stage is diagnosed in people with AMD risk factors. Early AMD is characterized by yellow deposit below the retina.
- Intermediate AMD: At this stage, there may be noticeable color changes in the retina, and the yellow deposits beneath it are larger than those in the early stage.
- Late AMD: With late AMD, the patient experiences noticeable vision loss.
Some of the risk factors for macular degeneration include:
- Age: As the name suggests, age is the most significant risk factor for AMD.
- Genetics: People with a family history of AMD are likely to also get it.
- Sex: Women are at a greater risk for developing macular degeneration compared to men.
- Smoking: Smoking and other poor lifestyle choices (such as having high cholesterol, being obese, and consuming saturated fats) can double your risk of developing macular degeneration.
Diagnosis and Treatment Options
Regular eye tests are necessary to diagnose AMD. The presence of drusen or pigment clumping beneath the retina is an indication of the disease.
The doctor may also show you an Amsler grid to look at. If any of the lines appear wavy, then it can indicate macular degeneration.
If the cause of your AMD is age-related, then the doctor may carry out an angiography or an Optical Coherence Tomography (OCT) procedure.
With an angiography, the doctor injects dye into a vein in your arm. As the dye reaches and flows through your retina, the doctor uses special equipment to take photographs. The photos will show any new vessels or vessels leaking blood into the macula. With the OCT procedure, the doctor can make the same observations without the use of dye.
Treatment and Management Options
Macular degeneration has no cure. However, there are a few measures you can take to mitigate the progression of the disease. One key step you can take is avoiding smoking, and make sure you have a healthy diet and exercise. You could also protect your eyes from ultra-violet light.
Treatment options for patients may include the following:
- Medications: Drugs prescribed may include ranibizumab (Lucentis), pegaptanib (Macugen), Aflibercept (Eylea), and bevacizumab (Avastin). These are anti-angiogenesis drugs used to inhibit the creation of blood vessels and leaking from the vessels beneath the retina. These drugs are particularly useful for wet macular degeneration and can restore the sight of the patients. However, the patient must take the treatment every time the blood vessels re-occur.
- Laser therapy: This procedure helps destroy abnormal blood vessel growth.
- Photodynamic laser therapy: With this procedure, a doctor injects a light-sensitive drug called verteporfin (Visudyne) into the blood, which is then absorbed into the damaging blood vessels. The doctor then shines a laser into your eye, which destroyed the medication and subsequently damaging the vessels.
- Low vision aids: These are electronic lenses that enlarge the images of things near your vision.
The type of treatment you receive will be based on your individual needs. Always be sure to speak with your doctor if you have questions or concerns, and they will help you create the best treatment plan to help manage your symptoms.