Dravet Syndrome Seizure Treatment Options People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome. Fintepla Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome. Medications for Dravet Syndrome Seizures Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity. Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects. Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals. [youmaylike] Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects. Dietary Approaches: The Ketogenic Diet For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures. The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet. Vagus Nerve Stimulation (VNS) Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe. VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments. Surgical Options In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved. Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery. Supportive Therapies While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include: Physical therapy: This helps improve mobility and strength, which can be affected by seizures. Occupational therapy: Helps individuals learn daily skills to live as independently as possible. Speech therapy: Helps improve communication skills, which may be affected by seizures. Ongoing Monitoring and Care Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options. The Best Approaches to Seizure Control While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.
What Causes Tardive Dyskinesia?
Mental health is something that is very much highlighted nowadays and rightfully so. Thankfully, we now have a variety medication and treatment options to help treat diseases, but sometimes they can have certain side effects. One example of this is a condition called tardive dyskinesia. So, what cause tardive dyskinesia? It may sound very foreign, but it is one of the usual side effects of certain medications for mental or mood disorders. In this article, you will find out what tardive dyskinesia is, what its symptoms are, what causes it and how it is treated.
What is Tardive Dyskinesia?
Tardive dyskinesia is a syndrome that affects the brain and nerves. It is characterized by involuntary movements of the arms, legs, or limbs, as well as involuntary gestures, such as sticking out of the tongue and sudden and repetitive blinking of eyes. Tardive dyskinesia is a side effect of taking antipsychotic medications which are used to treat people with conditions like schizophrenia, bipolar disorder, depression and other mental health or mood-related disorders. Cases have been increasing over the past years and around 500,000 people are affected in the U.S. Not everyone who takes antipsychotic medications will experience it, but it can occur in some people.
What Are the Symptoms of Tardive Dyskinesia?
Dyskinesia is a medical term for involuntary movements of the body. People with tardive dyskinesia may experience a sudden stiffness of muscles in portions of their body, causing jerky movements that they cannot control. This can occur in the muscles of the face and mouth. This includes fast blinking of the eyes, uncontrolled sticking out of the tongue, uncontrolled movements of the mouth, such as chewing, puckering the lips, puffing out cheeks and frowning.
Dyskinesia of the limbs can also affect extremities, causing uncontrollable wiggling of the fingers, tapping of the feet on the floor, flapping of arms, thrusting out of the pelvis and swaying from side to side. These movements can be fast or slow, but they can affect daily activities and some affected people will find it hard to work. This condition is hard to diagnose because symptoms may take months or years to appear and can occur even with the discontinuation of medication.
Tardive Dyskinesia Causes
Antipsychotic medications treat schizophrenia, bipolar disorders, depression and other brain conditions. These are also called neuroleptic drugs. These medications block the neurotransmitter dopamine, a chemical messenger of the body. Having a small amount of dopamine in the body causes jerky and uncontrolled movements seen in this condition.
The antipsychotic drugs or medications that can cause tardive dyskinesia are the following:
1. Haloperidol
This medication is used to treat various and certain mental or mood disorders like schizophrenia and schizoaffective disorders. This medication helps you to think clearly, feel less panic and prevents suicidal thoughts in people who are likely to harm themselves. It can also be used to treat Tourette’s syndrome, which also involves uncontrolled movements or twitching.
The side effects of Haloperidol include:
- Dizziness.
- Drowsiness.
- Lightheadedness.
- Difficulty urinating.
- Sleep disturbances.
- Headaches.
- Anxiety.
2. Fluphenazine
This is an antipsychotic drug that is used to treat schizophrenia and psychotic symptoms, such as hallucinations, delusions and hostility.
Using this medication can cause side effects such as:
- Upset stomach.
- Weakness or tiredness.
- Excitement.
- Anxiety.
- Insomnia.
- Nightmares.
- Dry mouth.
- Changes in appetite.
- Skin sensitivity.
- Rashes.
If the following symptoms occur, like constipation, difficulty in urinating, excessive sweating, jaw, neck and back muscle spasms, irregular heartbeat and fever, consult a doctor.
3. Risperidone
Also known as Risperdal, this is used to treat symptoms of schizophrenia as well as episodes of mania, aggression, self-injury and sudden mood changes. This is usually given to teenagers and children aged 5 to 16 years of age who have autism.
Risperidone has side effects such as:
- Nausea.
- Vomiting.
- Constipation.
- Heartburn.
- Dry mouth.
- Stomach pain.
- Dreaming more than usual.
- Agitation
- Anxiety.
4. Olanzapine
Also known as Zyprexa, this is used to treat schizophrenia in adults and teenagers. It is also used to treat bipolar disorder.
Its side effects include:
- Dizziness.
- Depression.
- Weakness.
- Difficulty sleeping.
- Weight gain.
- Constipation.
- Pain in joints.
- Late or missed menstrual periods.
- Decreased libido.
Serious side effects include seizures, changes in vision, swelling of muscles, excess sweating and difficulty in swallowing. If these symptoms occur, consult a doctor.
Treatment Options
Proper diagnosis is helpful in order to treat tardive dyskinesia early. The best way to avoid it is not taking any medication that can cause the condition. If the medication cannot be avoided or no alternative medications are available, the medicine can be given by starting with the smallest possible dose.
Natural remedies and adjuncts can also help, but there is no scientific basis that they are beneficial and needed in the treatment of tardive dyskinesia. Natural remedies include ginkgo biloba, melatonin, vitamin B6 and vitamin E.
If prescribing antipsychotic drugs cannot be avoided and symptoms occur, the two FDA-approved medications to treat tardive dyskinesia include Deutetrabenazine and Valbenazine. Both of these medications work in similar ways to regulate the amount of dopamine flow in the brain area in order to control certain movements in the body. Just like management of mood and mental disorders, managing tardive dyskinesia is also done on a case-to-case basis. At the end of the day, your doctor will prescribe what is best for your situation.
