Dravet Syndrome Seizure Treatment Options People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome. Fintepla Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome. Medications for Dravet Syndrome Seizures Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity. Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects. Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals. [youmaylike] Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects. Dietary Approaches: The Ketogenic Diet For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures. The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet. Vagus Nerve Stimulation (VNS) Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe. VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments. Surgical Options In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved. Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery. Supportive Therapies While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include: Physical therapy: This helps improve mobility and strength, which can be affected by seizures. Occupational therapy: Helps individuals learn daily skills to live as independently as possible. Speech therapy: Helps improve communication skills, which may be affected by seizures. Ongoing Monitoring and Care Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options. The Best Approaches to Seizure Control While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.
Chemo Side Effects
Chemotherapy is a treatment used to kill rapidly growing cells in your body, and chemo side effects can occur. The cells in our body have a "self-destruct" mechanism, but sometimes they can lose this ability and continue to grow into what is known as a tumor. These tumors then compete with healthy cells for nutrients and oxygen, thereby destroying the body.
The downside of chemotherapy is that it does not distinguish between fast-growing cells of the body and tumor cells. This lack of distinction between these cells results in the common side effects of chemotherapy treatment. Some rapidly growing cells in the body include cells in the inner lining of the mouth, nails, hair, and even blood cells. These areas are often affected during the treatment process.
Why Would You Undergo Chemotherapy?
Aside from using chemotherapy as the only treatment option to kill cancer cells, it is also used:
- As an adjuvant treatment to kill cancer cells after surgery may have been done.
- To shrink the size of tumors to enable surgery or radiation to eliminate the rest. This is referred to as neoadjuvant treatment.
- It can also be used as a palliative measure to relieve you of the symptoms associated with cancer.
Chemotherapy Treatment
Chemotherapy treatment can be in the form of pills, creams, and injections, administered within the hospital or at home by an oncologist. It is advisable to have a family member drive you when you receive your first course because some people have reported feeling drowsy after receiving treatment.
During the treatment, you will be closely monitored through tests to know the effectiveness of the chemotherapy, and so the doctor can adjust it according to how you respond to it.
Common Side Effects of Chemotherapy
Due to the presence of rapidly dividing cells around the body and chemotherapy’s inability to separate them, the side effects affect multiple organs in the body. The most affected systems include the mouth, bone marrow, digestive tract, hair, and reproductive organs.
Chemotherapy reduces cells that provide immunity and protect you from infections. They also affect the red blood cells, which transport oxygen around your body, and the platelets, which stop you from bleeding out by forming a clot. All these manifest as:
- Body weakness
- Easy bruising
- Pale skin
- Getting sick more frequently
- Blood in stools and vomit
You may also experience side-effects in the mouth and digestive systems. For the mouth, these include reduced saliva production, painful sores in the mouth, on the lips, tongue, and gums, which make eating and swallowing difficult. The loss of healthy cells in your mouth will also cause altered taste sensations and a yellowish covering on the tongue, ultimately leading to weight loss. For the digestive systems, common side-effects include constipation, diarrhea, nausea, and vomiting. All of these can lead to weight loss and weakness.
Chemotherapy also affects the reproductive system and causes alterations in the hormonal levels of both men and women. Infertility can occur in both men and women from chemotherapy treatment, which could be temporary or permanent. Women experience altered periods, hot flashes, vaginal dryness, painful intercourse, an increased risk of vaginal infections, and early onset of menopause. Men experience reduced sperm count and libido.
Although individuals on chemotherapy treatment experience various symptoms, it does not hinder them from having healthy sex lives. Pregnancy is, however, discouraged in females because the toxicity of the medications could cause congenital disabilities.
The changes to your hair, nails, and skin often cause the most visible symptoms. These include hair loss or Alopecia from the head, eyebrows, lashes, hands, and legs. Thankfully, this effect is reversible after the last dose of chemotherapy. There could also be skin irritation, dryness, and rashes, as well as discoloration and brittleness of the nails.
Other side-effects of chemotherapy medications include swelling or tingling sensation in the limbs, reduced urination, generalized body pain, and weakness.
How To Manage the Side Effects
Preparation is essential, and this includes detailed instructions on the type of medications and dosages you’ll have. You’ll receive several tests on your liver, lung, heart, kidneys, and other organs to ensure that you are healthy enough to begin chemotherapy. Your dentist will also examine your teeth to ensure there are no active infections that could cause complications during the treatment.
Also, make sure to discuss possible side-effects ahead of time with your doctor so you can plan for them. Planning could include:
- Preserving your eggs or sperms in case of infertility.
- Having a head wrap or wig for hair loss.
- Avoiding stressful activities and exposure to germs
- Drinking lots of water to help relieve the digestion problems
- Maintaining good oral and general body hygiene to prevent infections
- Eating healthy meals including fruits and vegetables
- Your doctor may prescribe anti-nausea medication to prevent vomiting
