How Cystic Fibrosis Affects Adults

How Cystic Fibrosis Affects Adults

Pamela Bandelaria |Mar 7, 2022

Cystic Fibrosis in Adults

One of the most common autosomal recessive diseases is cystic fibrosis (CF). It occurs in 1 in 2,500 to 3,500 newborns. Does this illness sound familiar? If it does not, do not worry. In this article, you will learn about cystic fibrosis in adults, including symptoms and how it affects different organs in the body.

What is Cystic Fibrosis?

Cystic fibrosis is an inheritable disease. In order for the disease to manifest, two copies of the abnormal gene must be present. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (a gene that encodes a chloride channel) causes problems in the CFTR protein, which leads to imbalances in the salt and water inside the cell. This imbalance leads to the body producing thick and sticky mucus. Mucus is ideally fluid and runny so that it can act as a lubricant in the body, but for people with CF it tends to clog tubes, putting you at risk of other health concerns.

Cystic fibrosis is also a multi-organ disease, as its effects are seen in different organs, such as the lungs, pancreas and the other gastrointestinal organs, the sinuses and sweat glands.

1. Symptoms in Lungs

Mucus in the lungs normally helps in the lubrication and trapping of foreign substances and microorganisms. The increased viscosity of mucus brought about by cystic fibrosis leads to mucus plugging of the bronchial passages and small airway ducts. This leads to obstructive lung disease and inflammation. It also provides a good habitat for the growth of bacteria, leading to pulmonary infection. Because of its effect on the lungs, people with this condition have significant respiratory problems leading to extreme difficulty in breathing over time.

2. Symptoms in the Gastrointestinal System

Normally, the pancreas secretes enzymes that empty into the small intestine to help with the digestion of food. For patients with cystic fibrosis, this is impaired because the thick mucus secretion blocks and clogs the pancreatic ducts, leading to pancreatic insufficiency. The release of pancreatic enzymes for digestion is compromised too. The impairment due to cystic fibrosis causes greasy stools and difficulty of absorption of nutrients, especially the fat-soluble ones (vitamins A, D, E and K).

Not only that, but because the pancreatic enzymes are not released, it results in inflammation within the pancreas which can lead to destruction of pancreatic tissue and eventually pancreatic failure. Further damage of the pancreas can lead to complications that are similar to type 1 diabetes mellitus.
Duct obstruction also affects the gallbladder and liver, leading to liver cirrhosis and gallbladder disease, with an increased risk of gallstone formation.

3. Symptoms in the Sinuses and Sweat Glands

Obstruction in the sinus passages leads to increased inflammation. Cilia, which are hair-like structures that line the sinus passageways, are impaired. Cilia are part of the respiratory system’s defense and trap potentially-harmful substances, including bacteria that can lead to increased bacterial growth and sinusitis. Dysfunction also occurs in the sweat glands, and it causes the sweat in skin to have a higher salt concentration. In severe cases, this can lead to dehydration.

How is It Treated?

Cystic fibrosis can be diagnosed at birth through newborn screening tests. Because it can be detected early, treatment can also be started early and optimized. Treatment is also multi-factorial and patients are usually managed by a team of specialists.

The main goal in the treatment of cystic fibrosis is to ensure that all the organs affected by the disease are not damaged and function optimally for as long as possible.

Because cystic fibrosis has a significant impact on the lungs, one of the goals of treatment is to maintain lung function and avoid further impairment by controlling infection and inflammation.

Antibiotics are given to control infection and adequate oxygenation is provided by bronchodilators. Anti-inflammatory medications are given to control inflammation. If there are signs of respiratory distress, oxygenation and breathing are supported by using devices such as nasal cannulas or a bilevel positive airway pressure. Nutritional support is also important as malabsorption of important nutrients can lead to poor weight gain and weaker immunity. By addressing all these concerns, treatment is not only multi-factorial, but also holistic.

In Conclusion

While many people believe CF is limited to the lungs, this is not true. Cystic fibrosis in adults can occur in other areas of the body, affecting the sinus cavities and digestive tract. If you believe you are at risk, talk to your doctor as soon as possible.

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Experiencing Frequent Urination or Leaking? You Might Have OAB

Staff Writer | March 7, 2022

How You Can Stop the Leakage Overactive bladder (OAB) refers to symptoms rather than a disease. It is used to describe the phenomenon of people experiencing urinary issues. Some products that help include Comfort Medical and PureWick. Treatments for an Overactive Bladder Treatments will vary depending on what exactly is wrong. Most cases of OAB do not require invasive intervention. Some of the most common treatments recommended are: Lifestyle changes: Introducing some exercise routines in your life can help strengthen muscles. Plus, it can fight obesity, which can help reduce the chances of suffering from OAB. Some experts recommend that you try to put your bladder on a schedule. By training your bladder to know what you can and cannot do, you can shape your behavior. Some also recommend “bladder training,” where you try to delay urination when you feel the urge to grow in increasing durations to strengthen your ability to “hold it”. Using protective, absorbent padding can be a last resort if you cannot adjust your behavior. This will allow you to avoid embarrassing accidents. Medication: Some prescription medications can be sued to help strengthen areas of the body or “relax” your bladder. Some common medications include: tolterodine, darifenacin, fesoterodine and mirabegron. Botox: Botox does not just flatten our wrinkles. Small injections of Botox into bladder tissue can offer temporary relief from bladder problems. It sometimes has the side effects of increased UITs and urinary retention. Nerve stimulation: Percutaneous tibial nerve stimulation has also been shown to help with OAB. It works by sending electrical signals from a nerve in your leg to nerves connected with bladder control. Surgery: For those suffering from severe symptoms, surgery is the last option. It can involve increasing the size of the bladder or replacing the bladder with a surgically constructed replacement. Comfort Medical vs. PureWick Comfort Medical provides catheters inserted into the urethra to manage urinary incontinence internally, whereas PureWick offers an external catheter solution using an absorbent wick for non-invasive urine collection. Getting a Diagnosis Anyone can suffer from OAB. Unfortunately, many adults are too embarrassed to ask for help or do not realize their conditions are treatable. Roughly 30% of men and 40% of women in the U.S. suffer from overactive bladder symptoms. While no one is immune to these problems, there are some conditions that increase your chances of suffering from OAB. These can include: Brain damage Hormonal changes Pelvic muscle weakness Urinary tract infections (UTI) Taking certain medications Stoke, multiple sclerosis (MS) or other conditions impacting the central nervous system (CNS) Signs and Symptoms of OAB Some people fail to realize that their bathroom habits are not normal. Familiarizing yourself with the symptoms can allow you to better recognize the signs of OAB which will get you one step closer to treatment. Those suffering from an overactive bladder may experience the following: Urgency: OAB’s main symptom is that sufferers experience strong, sudden urges of needing to go to the bathroom. Typically, the need to go to the bathroom will build up over time. While it is easy to ignore these feelings until you have to go, when all you feel is a sudden urge to go immediately or risk having an accident, there may be something wrong. Leaking: Suffering from something called “urge incontinence” is rather common when you suffer from an overactive bladder. It means that sometimes during these sudden urges, you will leak a little urine. You must distinguish it from people suffering from stress urinary incontinence (SUI). Rather than leak during an episode of sudden urges, those suffering from SUI leak during physical activities which would strain the region including sneezing, laughing or stretching. Frequent urination: Frequently needing to use the bathroom is not always a sign that you drank too much. If you constantly need to go to the bathroom a lot throughout the day (especially to the point where it begins to interfere with your daily life), you may be suffering from OAB. Waking up to pee: The same can be said for those who have to wake up to go to the bathroom. A fully functioning bladder is normally able to hold urine while someone is sleeping. If you frequently have to get up during the night because you need to use the bathroom, you should talk to your doctor about OAB. [youmaylike] Causes of an Overactive Bladder Because OAB is not one disease, but rather an umbrella term to characterize specific urinary symptoms, physicians will need to investigate the underlying cause of your problems. The origin of problems usually arises from areas in the urinary tract itself. Areas of the body likely responsible for an overactive bladder include the following: Kidneys. Bladder. Ureters. Urethra. Sphincter muscle. In Conclusion Talk to a trained physician if you believe you or a loved one may be suffering from an overactive bladder. They will be able to offer expert advice on how to handle your case. This is not the same as someone who suffers from an inability to control their bladder from emptying on its own.

What You Need to Know About Hyperkalemia

Staff Writer | March 7, 2022

What is Hyperkalemia? Hyperkalemia is the medical term for when you experience high potassium levels in your blood. In terms of numbers, a healthy individual will have between 3.6mmol/L and 5.2mmol/L in their body. Anything higher than that is officially classified as hyperkalemia. Between 5.3mmol/L and 6.0mmol/L is mild hyperkalemia. Between 6.1mmol/L and 7.0 mmol/L is moderate hyperkalemia. Above 7mmol/L is severe hyperkalemia. Why is Too Much Potassium Harmful? Potassium is healthy for you in the right doses. Your body needs it to function properly. It is an incredibly important substance that plays a vital role in your nerves and muscle cells. This means that you need it for your heart to work. Like with anything else, too much of a good thing is not good. The more common form of hyperkalemia only rears mild to moderate symptoms. The most extreme severities of this condition can result in death. Symptoms of Hyperkalemia Generally, until your hyperkalemia is severe, you may not even experience or recognize any of the symptoms. As your levels soar to dangerous heights, you may experience one or more of the following symptoms: Muscle weakness or pain. Your muscles may feel tender or even painful. It may feel as though you just finished an intense workout. Fatigue. Despite getting adequate sleep, you may feel sluggish and tired the entire day or you may be too weak to function. Nausea. An upset stomach may or may not be accompanied by some vomiting. This is a common sign of hyperkalemia. Breathing problems. You may find it difficult to take deep breaths or find yourself forced to gasp for air. Irregular heartbeat. Your heart may beat funnily or feel weird in your chest. This is always a symptom to bring up to your doctor immediately. Chest pains. Chest pains ranging from mild to severe are a common result of hyperkalemia. In the most extreme cases, hyperkalemia left untreated can cause cardiac arrest and death. What Causes Hyperkalemia? There are several known causes of hyperkalemia, which range from medical disorders to lifestyle habits. Hyperkalemia is known to have many causes. These include: Kidney Disease The main function of a kidney is that it filters everything in your body. When there is something wrong with your kidneys, it can mess up all sorts of vitamin levels in your body. Potassium is just one of them. Heart Disease Heart disease results in a variety of factors that make it more likely to have problems with your potassium levels. Hormone Imbalances Having abnormally low amounts of aldosterone can result in potassium problems. This can happen due to a variety of conditions, including hypoaldosteronism and congenital adrenal hyperplasia. Diabetes A lack of insulin may be the culprit behind enhanced potassium levels. This is something that would be more likely to occur if diabetes is undermanaged (or undiagnosed). [youmaylike] Medications Side effects of certain medications could cause potassium levels to rise. You may be surprised to see that some common medications will do this. Non-steroidal, anti-inflammatory drugs, such as ibuprofen and naproxen, will do it. Some of the other medications that can do this are heparin, mannitol, beta-blockers, angiotensin inhibitors, calcium blockers, and cyclosporine. Diet Medications are not the only way to introduce potassium to the body. There are lots of foods that can lead to heightened potassium levels. Many of these foods are healthy, but to a person at risk for hyperkalemia, they can be dangerous if not eaten in responsible quantities. There is also the chance that you are a victim of pseudo hyperkalemia. As the name suggests, you do not have any potassium problems. Sometimes due to faulty equipment, you will get a wrong reading. Hyperkalemia Treatment To determine how to treat hyperkalemia, it is important that you first identify the cause of it in yourself. Getting advice from a licensed medical physician is the best way to determine your treatments. Diet Change Changing your diet can do wonders for your health. If you battle hyperkalemia, consider limiting your intake of foods rich in potassium like cucumbers, pumpkins, potatoes, bananas, grapefruit, oranges, eggplants and peas. Intravenous Calcium or Insulin and Glucose Medical injections are an efficient and fast technique to lower calcium levels. When diet alone is not enough, these can drop your potassium levels to a safer place in a pinch. Albuterol Doctors may also administer albuterol alone or in addition to other treatments. Unfortunately, this does not work for everyone. Changing Medications If a certain medication is causing dangerous, unwanted side effects, you may want to talk to your doctor about switching.

The Top 10 Vitamins and Supplements for Women During Menopause

Danielle Kemp | March 7, 2022

Helping With This Natural Phase for Older Women Menopause is a natural phase in a woman’s life and marks the end of her reproductive years. While it brings significant hormonal changes, it doesn’t have to be a time of discomfort or distress. By incorporating specific vitamins and supplements into their daily routine, women can manage the uncomfortable symptoms that come with menopause. Read on as we discuss the 10 best vitamins and supplements that can support women during this transitional phase. 1. Calcium and Vitamin D During menopause, there is a natural decrease in estrogen levels. This can lead to bone loss and increase the risk of osteoporosis. Calcium and vitamin D are crucial for maintaining good bone health. Calcium supports the formation and maintenance of strong bones, while vitamin D aids in calcium absorption. Dietary sources of calcium include dairy products, leafy greens and fortified foods. Vitamin D can be obtained through sunlight exposure and fortified foods, but supplements may be necessary to meet the recommended daily intake. 2. Omega-3 Fatty Acids Omega-3 fatty acids are essential for overall health, especially during menopause. They have been shown to reduce inflammation, support heart health and improve mood. Additionally, they can alleviate menopausal symptoms such as hot flashes and joint pain. Fish, particularly fatty fish like salmon and sardines, is an excellent source of omega-3s. Fish oil supplements are available that can help ensure optimal intake of these fatty acids. 3. B Vitamins B vitamins, including B6, B9 (folate) and B12, are crucial in maintaining energy levels and supporting emotional well-being. They can help combat fatigue, mood swings and memory lapses commonly experienced during menopause. Foods rich in B vitamins include whole grains, legumes, leafy greens, eggs and fortified cereals. Taking a B-complex supplement is also a good way of ensuring adequate intake. 4. Magnesium Magnesium is an essential mineral that supports many biochemical reactions in the body. During menopause, magnesium can alleviate mood swings, reduce anxiety and improve sleep quality. It has also been shown to aid in maintaining bone density and muscle function. Dietary sources of magnesium include nuts, seeds, legumes, whole grains and leafy greens. Women who are concerned about a lack of magnesium in their diet can also take supplements to ensure optimal intake. 5. Black Cohosh This herbal supplement has been traditionally used to manage menopausal symptoms, including hot flashes, night sweats and sleep disturbances. It is believed to mimic the effects of estrogen in the body. While research results are mixed, many women find relief while taking black cohosh. It is important to consult with a healthcare professional before starting any herbal supplement, as it may interact with certain medications or have side effects. [youmaylike] 6. Soy Isoflavones These plant compounds have a similar structure to estrogen. They are known as phytoestrogens and can help alleviate menopausal symptoms. Products such as tofu, soy milk and tempeh are rich sources of isoflavones, but there are also supplements available. 7. Vitamin E Vitamin E is a powerful antioxidant that can help alleviate menopausal symptoms, particularly hot flashes and vaginal dryness. It works by reducing oxidative stress in the body. Good dietary sources of vitamin E include nuts, seeds, spinach and broccoli. There are also supplements available if you are concerned about achieving adequate intake. 8. Probiotics Menopause can sometimes disrupt the balance of gut flora, leading to digestive issues and a weakened immune system. Probiotics are beneficial bacteria that support digestive health and immune function. They help to alleviate bloating, gas and constipation and are available in fermented foods like yogurt, sauerkraut and kimchi. 9. Evening Primrose Oil Evening primrose oil is derived from the seeds of the evening primrose plant. These seeds are rich in gamma-linoleic acid (GLA), which is an omega-6 fatty acid, and have been found to reduce hot flashes, improve skin elasticity and relieve breast pain associated with menopause. Evening primrose oil is available in capsule form and should be used under the guidance of a healthcare professional. 10. Ginseng Ginseng, particularly the Panax ginseng variety, has been used in traditional medicine to alleviate menopausal symptoms. It may help reduce fatigue, improve cognitive function and enhance overall well-being. It is available as a supplement and should be used with caution as it can interact with certain medications and cause side effects in some individuals. Final Notes It's important to note that while vitamins and supplements can be beneficial during menopause, they should not replace a balanced diet and a healthy lifestyle. It's always advisable to consult with a healthcare professional before starting any new supplements, especially if you have any underlying health conditions or are taking medications. Incorporating essential vitamins and supplements into their daily routines can provide much-needed support for women during menopause. By understanding their unique needs and consulting with healthcare professionals, women can navigate this transformative stage with greater comfort and vitality.