What is Gout? To answer "what is gout?" you should know it is a relatively frequently occurring type of arthritis. The common condition is the result of having elevated levels of uric acid in your bloodstream. This excess of uric acid leads to uric acid crystal formation in the joints, notoriously the one on the base of the big toe. These crystals cause a number of alarming and uncomfortable symptoms. [youmaylike] Signs and Symptoms Gout can manifest in several different ways depending on the patient. In general, gout can be characterized as episodes of joint pain, swelling and redness. The pain itself can occur out of nowhere, and either turn into a general discomfort or disappear. Episodes of gout can occur abruptly and it is not uncommon for them to start in the middle of the night. The big toe is one of the most common appendages that is affected, although it can also affect the forefoot, knees, ankles, knees, elbows and bones in your hand or wrist. Types of Gout Although these all refer to the same illness, there are “types” of gout, which indicate different stages of the illness. Asymptomatic hyperuricemia: This is the earliest stage of the disease. Some of the crystals may be causing some tissue damage, but symptoms may be mild to non-existent. Acute: This refers to a more extreme event. In acute gout, patients experience acute episodes of intense pain in a “flare” that lasts a couple of days. Different events can trigger the onset of symptoms, including stress or alcohol. They may also appear seemingly out of nowhere. Intercritical: When flares die down but you still have gout, your body is still depositing excess urate crystals into your joint tissue. These periods are called intercritical gout, where you may not really feel symptoms but the damage is still happening. Chronic tophaceous: This is the most extreme form of the disease. It is debilitating and can get to the point where permanent and extreme damage has been done to the joints and kidneys. Huge lumps and pain may be chronically present at this point. There is also a condition that is referred to as pseudogout. This condition is not a form of gout, but it is very similar in terms of the symptoms someone might experience. These similar symptoms are not caused by urate crystals, but rather calcium pyrophosphate crystals. Generally, symptom expression is less severe in comparison to traditional gout. Treatment Options There are several different medications that may be prescribed to treat gout. Different medications may be used depending on the types of symptoms you are experiencing or expressing a desire to reduce. These medications include some which may manage uric acid levels (aloprim, zyloprim, ulroic or lesinurad), inflammation (colcrys) or painkillers. Talk to your doctor to find a solution which is best for you. Natural Remedies for Gout One of the best natural remedies for gout is making lifestyle changes. By making these tiny lifestyle changes, you will be able to minimize the flares of gout or even prevent it entirely. If you know that you have had a flare before or are at risk for developing gout, consider taking the following steps: Drink lots of water: Drinking the recommended amount of water a day can help keep your body in tip-top shape. Achieve a healthy body weight: Obesity puts a lot of pressure on your body. If you are overweight, try to achieve and maintain healthy body weight. Stay sober: Alcohol can be an especially big trigger for gout. Consider abstaining from alcohol use in order to keep your gout under control. Change your diet: To limit the about of uric acid coming into your body, make changes to your what you eat. There are some foods that will encourage very high levels of uric acid in your body, including: anchovies, sardines, mackerel, herring, lobster, shrimp, mussels, scallops, mushrooms, organs (especially liver and kidneys), fast food, soda and alcohol. Consider having healthier foods that encourage an overall healthy diet. Some of the best foods for managing gout include: Yogurt and skim milk. Nuts and grains. Fresh fruits and veggies. Potatoes. Most importantly, be sure to practice moderation. When to See a Doctor As soon as you notice that your symptoms are interfering with your daily life, you should make an appointment with a medical professional. This is a good practice in general. Even if you do not have gout, alarming symptoms may be a sign of a more serious underlying condition.
Dravet Syndrome Seizure Treatment Options
People with Dravet Syndrome often experience a variety of different types of seizures, including prolonged ones. To help, there's Fintepla, a medication approved to treat seizures caused by Dravet syndrome.
Fintepla
Fintepla works by targeting the brain’s electrical activity, helping to reduce the number and severity of seizures. Doctors prescribe Fintepla when other medications haven’t been effective in controlling seizures. This treatment has shown positive results in many patients, making it an essential option for managing Dravet syndrome.
Medications for Dravet Syndrome Seizures
- Clobazam: This drug is often prescribed alongside other treatments. It helps to control seizures by calming the brain and reducing electrical activity.
- Valproate: This medication is used to control a variety of seizure types. However, it is not always the best choice for younger children due to its potential side effects.
- Topiramate: Used to prevent seizures, this medication works by affecting the brain's electrical signals.
Doctors may need to try different combinations of medications to find what works best for the individual. It’s important for patients and their families to closely monitor the medications and any side effects.
Dietary Approaches: The Ketogenic Diet
For some individuals with Dravet Syndrome, medications may not be enough to control seizures. In these cases, dietary treatments, such as the ketogenic diet, can be very helpful. The ketogenic diet is high in fats and low in carbohydrates, and it forces the body to use fat for energy instead of carbohydrates. This change in metabolism can help reduce seizures.
The ketogenic diet should only be followed under the supervision of a doctor or dietitian, as it requires careful planning to ensure that the person gets the proper nutrition. Some children with Dravet Syndrome may experience a significant reduction in seizures after starting the ketogenic diet.
Vagus Nerve Stimulation (VNS)
Vagus Nerve Stimulation (VNS) is another treatment option for Dravet Syndrome. This therapy involves implanting a small device under the skin in the chest. The device sends electrical signals to the brain through the vagus nerve, which can help reduce the frequency and severity of seizures. The device can be programmed to give a burst of electrical stimulation when a seizure is detected, helping to stop the seizure or make it less severe.
VNS is often considered when medications and diet do not provide enough seizure control. It is typically used in combination with other treatments.
Surgical Options
In some rare cases, surgery may be an option for treating Dravet Syndrome. If seizures are only coming from one part of the brain and medications do not help, surgery may be performed to remove that part of the brain. This surgery is called a lobectomy or hemispherectomy, depending on the area of the brain involved.
Surgical options are not suitable for everyone, and doctors will carefully evaluate the risks and benefits before recommending surgery.
Supportive Therapies
While medications and other treatments are important for managing seizures, other therapies can be helpful in improving quality of life for individuals with Dravet Syndrome. These may include:
- Physical therapy: This helps improve mobility and strength, which can be affected by seizures.
- Occupational therapy: Helps individuals learn daily skills to live as independently as possible.
- Speech therapy: Helps improve communication skills, which may be affected by seizures.
Ongoing Monitoring and Care
Managing Dravet Syndrome requires ongoing care. It is essential for individuals with the condition to have regular check-ups with their doctor to monitor their progress and adjust treatment plans as needed. Seizures can sometimes change over time, and it is important to stay flexible with treatment options.
The Best Approaches to Seizure Control
While Dravet Syndrome can be challenging, there are many treatment options available. With the right combination of medications, diet, therapy and support, people with Dravet Syndrome can lead fuller lives. It is important to work closely with healthcare providers to find the best treatment plan for each individual.